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Year : 2023  |  Volume : 14  |  Issue : 1  |  Page : 23-27

Effect of two different antifibrinolytic agents on platelet-rich fibrin: An in vitro comparative study

Department of Periodontology, K.S.R. Institute of Dental Science and Research, Tiruchengode, Tamil Nadu, India

Correspondence Address:
Dr. H Esther Nalini
Department of Periodontology, K.S.R. Institute of Dental Science and Research, Tiruchengode - 637 215, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/srmjrds.srmjrds_139_22

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Background: Platelet-rich fibrin (PRF) is a potent autologous regenerative material used in periodontal regeneration. PRF collapses easily into the periodontal defect due to its faster resorption rate and lesser rigidity. The degradation time of PRF has a direct impact on the clinical outcome. Aim: This study aimed to compare and analyze the effect of two different antifibrinolytic agents on the degradability of PRF membranes. Materials and Methods: Twenty-one PRF membranes were randomly divided into three groups: Group 1 – Conventional PRF obtained by adding normal saline (Control), Group 2 – PRF obtained by adding 200 mg tranexamic acid (TXA), and Group 3 – PRF obtained by adding 250 mg epsilon aminocaproic acid (EACA). After storing at room temperature in normal saline, PRF membranes were retrieved at 1st, 2nd, and 3rd weeks and the percentage of remaining weight was calculated. ANOVA is used for the statistical comparison of the data between groups. Results: In comparison to the baseline, the mean PRF weight was decreased in all groups in the 1st, 2nd, and 3rd weeks. In the 1st, 2nd, and 3rd weeks, the mean percentage of the remaining weight of PRF membrane in Group 1, Group 2, and Group 3 were 69.53 ± 12.96, 36.23 ± 9.28, and 17.43 ± 4.75 respectively. The statistical significance with the percentage of the remaining weight of the PRF was obtained in 3rd week with a P = 0.029. Conclusion: TXA efficiently delayed the degradability of the PRF membrane compared to EACA under experimental conditions.

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