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Year : 2016  |  Volume : 7  |  Issue : 4  |  Page : 235-241

Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II)

Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur, Maharashtra, India

Correspondence Address:
Rekha Bhaskar Chaudhari
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur - 444 003, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-433X.195635

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Oral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity. Despite considerable advances in diagnostic and therapeutic field, its prognosis remains poor. Grading by histopathological features does not influence prognosis until deeply invasive margins are evaluated by pathologists. The most invasive part of malignant tumor reflects disturbance in molecular mechanism, alteration in gene expression that controls cell differentiation, growth, death (apoptosis) as well as interactions between cancer cells and stromal components that may lead to the formation of oncofetal extracellular matrix, enabling tumor cell phenotype transition and migration. In recent years, analysis of cell proliferation, DNA content, and epithelial-mesenchymal transition (EMT) phenomenon has been used in an attempt to identify new prognostic indicators. Great interest is also shown in matrix metalloproteinase which plays a key role in invasion and metastasis. This review focuses on altered pathways in OSCC at gene expression and protein level, role of proteinases and EMT phenomenon in tumor progression, invasion, and metastasis with respect to invasive tumor front.

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