Print this page Email this page | Users Online: 1121
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2015  |  Volume : 6  |  Issue : 4  |  Page : 234-239

Myofibroblasts: Functions, evolution, origins, and the role in disease


Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur, Maharashtra, India

Correspondence Address:
Rekha Bhaskar Chaudhari
Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Nagpur, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-433X.156219

Rights and Permissions

Fibroblasts are ubiquitous mesenchymal cells, normally present in the stroma of many tissues of the body. They exhibit spindle shape morphology. There is phenotypic heterogeneity among fibroblasts. Fibroblasts are generally stress shielded by cross-linked extracellular matrix (ECM). This protective structure is lost as it differentiates to myofibroblasts (MFs). MFs are characterized by bundles of actin microfilaments (stress fibers) containing α-smooth muscle actin (α-SMA). Diverse cell types contribute to the appearance of MF subpopulation. A soluble factor transforming growth factor-β1 is considered a major growth factor that directly promotes MF development by inducing α-SMA expression. Modulation of fibroblast to MF represents a key event in wound healing process. They are also known to be involved in diverse reactive proliferative conditions, pathological remodeling, fibrosis, oral submucous fibrosis and in stroma of invasive and metastatic carcinoma odontogenic cysts/tumors and odontogenic cysts/tumors. This review describes its functions, evolution, multiple origins, and highlights on its role in the pathological state in relation to the oral cavity.


[FULL TEXT] [PDF]*
Print this article     Email this article
Next article
Previous article
Table of Contents

Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Citation Manager
Access Statistics
Reader Comments
Email Alert*
Add to My List*
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3613    
    Printed59    
    Emailed0    
    PDF Downloaded484    
    Comments [Add]    
    Cited by others 2    

Recommend this journal