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ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 3  |  Page : 175-179

A clinical study of serum alkaline phosphatase and calcium level in type 2 diabetes mellitus with periodontitis among the south Indian population


Department of Biochemistry, SRM Dental College, Ramapuram, Chennai, India

Correspondence Address:
D S Pushpa Rani
Department of Biochemistry, SRM Dental College, Ramapuram, Chennai 600 089. Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-433X.107396

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Aim: To evaluate the association of serum alkaline phosphatase (ALP) and calcium level in type 2 diabetes mellitus with periodontitis. Materials and Methods: In this study, a total of 240 subjects, aged 34-42 years were selected and was divided into four groups as 60 healthy individuals (group A), 60 type 2 diabetes mellitus without periodontitis (group B), 60 type 2 diabetes mellitus with periodontitis (group C), and 60 non-diabetes mellitus with periodontitis (group D). Blood samples were collected after an overnight fast for the estimation of serum glucose, ALP, and calcium using glucose oxidase-peroxidase (GOD-POD), p-Nitrophenyl Phosphate (p-NPP), and o-Cresolphthalein Complexone (OCPC) methods, respectively. Results: The concentration of serum ALP and calcium showed a significant increase ( P < 0.0001) in type 2 diabetes mellitus patients with periodontitis (group C) when compared to control. Conclusion: Increased serum ALP and calcium level could be often associated with the alveolar bone loss and tooth loss in type 2 diabetes mellitus with periodontitis among the South Indian population.


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